Hormone NSL3 predicting healthy aging in men

Hormone NSL3 predicting healthy aging in men

Researchers have discovered that a hormone produced in boys during puberty plays a vital role in predicting whether they will develop certain diseases later in life.

scientists University of Nottingham They discovered a new insulin-like peptide hormone called (England). INSL3, remains stable for a long time and constitutes an important early biomarker for the prediction of age-related diseases. Their latest findings have been published «Boundaries in Endocrinology».

INSL3 is produced by the same cells in the testicles that make testosterone, but unlike testosterone, which fluctuates throughout a man’s life, INSL3 remains stable and is the same throughout a man’s life, with an almost flat level at puberty, only slightly decreasing in old age. . This makes it the first clear and reliable predictive biomarker of age-related morbidity compared with other measurable parameters.

The results show that the level of INSL3 in the blood correlates with a range of age-related diseases such as bone weakness, sexual dysfunction, diabetes, and cardiovascular disease.

The discovery of the stable nature of this hormone is very important because it means that a man with high INSL3 levels when he was young will continue to have it as he ages.

But someone who has low INSL3 when young will have low INSL3 as they get older, making them more prone to typical age-related diseases. This opens up exciting possibilities for predicting age-related diseases and finding ways to prevent their onset with early intervention.

The investigation was conducted by Ravinder Anand-Ivell and Richard Ivelland the last of the last three studies on this hormone.

Ravinder Anand-Ivell explains, “The holy grail of aging research is to reduce the fitness gap that arises as people age. Understanding why some people are more prone to developing disability and disease as they get older helps people not only live longer lives, but also lead healthy lives as they age. “The discovery of our hormone is an important step towards understanding this and will help alleviate the care crisis we face not only individually but also as a society.”

The team analyzed blood samples from 3,000 men from 8 regional centers in northern, southern, eastern and western Europe, including England, with two samples taken four years apart. The results showed that, unlike testosterone, INSL3 was maintained at constant levels in individuals.

The holy grail of aging research is closing the fitness gap that arises as people age.

The study also showed that the normal male population, even when young and relatively healthy, exhibits approximately 10-fold wide interindividual variation in blood INSL3 concentration.

Professor Richard Ivell adds:Now that we know the important role this hormone plays in predicting disease and how it varies among men, we focus on finding out which factors influence blood INSL3 levels the most.. Preliminary work suggests that nutrition early in life may play a role, but many other factors, such as genetics or exposure to certain environmental endocrine disruptors, may also play a role.”

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